Key result
Ketanserin reversibly inhibits pinacidil-induced KATP currents in mouse myocytes with a Ki of ~9.4 µM.
Population
Mouse ventricular myocytes
Design
Preclinical
Authors
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May explain ketanserin's antiarrhythmic effects via K(ATP) inhibition; hypothesis-generating in mice, clinical validation required.
Effect estimate: Ki 9.36 microM
Ketanserin directly inhibits the ATP-sensitive potassium channel in mouse ventricular myocytes, suggesting a potential mechanism for its antiarrhythmic activity in ischemic/reperfused hearts.
Ju et al. (2006) studied this question. Ketanserin was evaluated on Inhibition of pinacidil-induced K(ATP) current (Ki 9.36 microM). Ketanserin reversibly inhibited pinacidil-induced K(ATP) current in mouse ventricular myocytes in a concentration-dependent manner with a Ki value of 9.36 microM.
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