What is the clinical evidence from this study?

Study design: Other. Intervention: Ketanserin. Primary outcome: Action potential duration (APD) lengthening and potassium current (IKr) reduction.

What does this research mean for the field?

Ketanserin prolongs cardiac action potential duration by directly blocking the IKr component of delayed outward potassium current via its benzoyl-piperidine moiety rather than through 5-HT2A/2C receptor antagonism. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 1, 1995Journal of Cardiovascular Pharmacology

Investigation of the Mechanism by which Ketanserin Prolongs the Duration of the Cardiac Action Potential

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Key result

Ketanserin prolongs APD and reduces IKr in cardiomyocytes via its benzoyl-piperidine moiety.

Population

Guinea pig isolated papillary muscles and isolated myocytes

Design

Preclinical

Authors

BGBruno Le GrandBone Therapeutics JTJean‐Michel TalmantPierre Fabre (France)JRJean-Pierre RieuPierre Fabre (France)

Discussion

Member takes

Implication

May warrant QT monitoring with ketanserin; leaves open human translation and class effects of benzoyl-piperidine compounds.

Structured PICO

Population

Guinea pig isolated papillary muscles and isolated myocytes

Intervention

Ketanserin (1-32 microM) and its congeners (pirenperone, PFBP), as well as non-congener 5-HT2A/2C antagonists (ritanserin, ICI 170809)

Outcome

Action potential duration at 90% repolarization (APD90) and potassium currents (IKr, IK1)surrogate

Ketanserin-induced action potential prolongation and arrhythmogenicity are mediated by direct blockade of myocardial potassium channels (IKr) via its benzoyl-piperidine moiety, not by 5-HT2A/2C receptor antagonism.

Cite This Study

Grand et al. (1995) studied this question. Ketanserin was evaluated on Action potential duration (APD) lengthening and potassium current (IKr) reduction. Ketanserin prolonged action potential duration and reduced the IKr component of the delayed outward current in guinea pig cardiomyocytes, an effect mediated by its benzoyl-piperidine moiety.

synapsesocial.com/papers/6aa8277cb05f134000da1343 https://doi.org/10.1097/00005344-199511000-00018

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Investigation of the Mechanism by which Ketanserin Prolongs the Duration of the Cardiac Action Potential

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Investigation of the Mechanism by which Ketanserin Prolongs the Duration of the Cardiac Action Potential

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider