Why the study?
Are microalbuminuria and chronic kidney disease associated with the development of heart failure with preserved versus reduced ejection fraction in a community-based sample?
Are microalbuminuria and chronic kidney disease associated with the development of heart failure with preserved versus reduced ejection fraction in a community-based sample?
Microalbuminuria is specifically associated with the future development of HFrEF, whereas CKD is associated with overall HF risk without subtype specificity.
Microalbuminuria may warrant closer HFrEF surveillance in community patients; leaves open causal links and subtype specificity beyond observational data.
Microalbuminuria was associated with incident HFrEF prospectively, and with LV systolic dysfunction cross-sectionally in a community-based sample. In contrast, CKD was modestly associated with overall HF but not differentially associated with HFpEF vs. HFrEF. The mechanisms responsible for the relationship of microalbuminuria to future development of HFrEF warrant further investigation.
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Nayor et al. (2017) studied this question.
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