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December 15, 1992Annals of Internal Medicine

Hormone Therapy To Prevent Disease and Prolong Life in Postmenopausal Women

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Authors

DGD GradyUniversity of California, San FranciscoSRSusan M. RubinPennsylvania State UniversityDPDiana B. PetittiUniversity of Arizona

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Overview

Clinical review reveals targeted benefits of hormone therapy in postmenopausal women with heart disease or prior hysterectomy, highlighting selective indication.

Key Points

  • To evaluate whether hormone replacement therapy effectively prevents disease and extends survival in postmenopausal women across different baseline health profiles.
  • Assessed indications and therapeutic strategies for hormone therapy across distinct postmenopausal patient subgroups.
  • Evaluated outcomes according to history of surgical menopause (hysterectomy) and baseline cardiovascular risk status.
  • Hormone therapy demonstrates probable therapeutic benefit and is recommended for women who have undergone a hysterectomy.
  • Therapy is supported for women presenting with established coronary heart disease or elevated cardiovascular risk, whereas evidence remains insufficient to define optimal management for other postmenopausal women.

Cite This Study

Grady et al. (1992) studied this question.

synapsesocial.com/papers/69deddfe488ed2d92be94246https://doi.org/10.7326/0003-4819-117-12-1016
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prospective Study of Estrogen Replacement Therapy and Risk of Breast Cancer in Postmenopausal Women1990 · 247 citations
  2. 2Hip Fracture Incidence and Mortality in New England1991 · 191 citations
  3. 3Menopause and Coronary Heart Disease1978 · 890 citations
  4. 4Estrogens and Endometrial Cancer in a Retirement Community1976 · 562 citations
  5. 5Estrogen Replacement and Coronary Artery Disease1990 · 374 citations