What question did this study set out to answer?

To compare the printability and biological capacity of four hydrogel bioinks to direct mesenchymal stem cell differentiation toward either hyaline cartilage or fibrocartilage in vitro.

October 7, 2016Biofabrication

A comparison of different bioinks for 3D bioprinting of fibrocartilage and hyaline cartilage

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To compare the printability and biological capacity of four hydrogel bioinks to direct mesenchymal stem cell differentiation toward either hyaline cartilage or fibrocartilage in vitro.
Mesenchymal stem cells (MSCs) were encapsulated in agarose, alginate, GelMA, or BioINK™ hydrogels and cultured for 28 days with TGF-β3 before assessment of type I and type II collagen deposition.
Print fidelity, post-printing MSC viability, and mechanical reinforcement via co-deposition with polycaprolactone filaments were characterized.
Alginate and agarose supported hyaline-like cartilage rich in type II collagen, whereas GelMA and BioINK™ generated fibrocartilage-like tissue containing both type I and type II collagen.
GelMA showed superior print fidelity, followed by alginate and agarose bioinks, with post-printing MSC viability remaining high (~80%) across all materials.
Co-depositing hydrogel bioinks with polycaprolactone filaments yielded composite constructs with bulk compressive moduli comparable to native articular cartilage.

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Implication

In vitro study demonstrates distinct cartilage phenotypes across hydrogel bioinks in stem cell cultures, highlighting the need to match biomaterials to specific joint tissues.

Cite This Study

Daly et al. (2016) studied this question.

synapsesocial.com/papers/69df23100f8b48d881614130 https://doi.org/10.1088/1758-5090/8/4/045002

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Implication

In vitro study demonstrates distinct cartilage phenotypes across hydrogel bioinks in stem cell cultures, highlighting the need to match biomaterials to specific joint tissues.

A comparison of different bioinks for 3D bioprinting of fibrocartilage and hyaline cartilage

Key Points

Discussion

Implication

Cite This Study

A comparison of different bioinks for 3D bioprinting of fibrocartilage and hyaline cartilage

Key Points

Discussion

Implication

Cite This Study

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