Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 15, 2026Environmental ToxicologyOpen Access

Cytogenotoxic Effects of Fluopyram in Allium cepa Root Cells Involving Microtubule Disruption

View Full Paper
Ask AI
Bookmark
Share

Authors

CCCarlos Filipe Camilo-CotrimNSNatanael Alves da SilvaGLGabriela Gomes Lima

Discussion

Loading...

Member takes

Overview

Evaluates cytogenotoxic effects of fluopyram on Allium cepa, indicating environmental risks for non-target organisms.

Key Points

  • To assess the cytogenotoxic effects of fluopyram on root meristem cells of Allium cepa.
  • Bulbs of Allium cepa were exposed to four concentrations of fluopyram-based pesticide.
  • Endpoints assessed included lipid peroxidation, cell viability, chromosomal alterations, and DNA damage.
  • Comet assay and mitotic analysis were performed to evaluate DNA strand breaks and cellular phases.
  • In silico docking analyses assessed interactions with tubulin.
  • Significant chromosomal aberrations and nuclear abnormalities were induced at all concentrations.
  • Low frequency of DNA strand breaks was observed, suggesting an aneugenic mode of action.
  • Mitotic analysis showed accumulation of cells in prophase, indicating chromosome missegregation.
  • Strong interactions between fluopyram ions and tubulin were demonstrated, supporting spindle-associated effects.

Cite This Study

Camilo-Cotrim et al. (2026) studied this question.

synapsesocial.com/papers/69df2b85e4eeef8a2a6b06c4https://doi.org/10.1002/tox.70096
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cytogenotoxic and Molecular Assessment of Pyrethrins on Non‐Target <i>Allium cepa</i> Roots2026
  2. 2Ecogenotoxicity of a flumioxazin-based herbicide in terrestrial plants.2025
  3. 3Efficacy of lufenuron on Allium cepa: cytogenotoxic, molecular and in silico docking studies2026
  4. 4Integrated in vivo and in silico assessment of fipronil-induced genotoxicity in Allium cepa2026
  5. 5STUDY OF CYTOGENETIC EFFECT OF PESTICIDE CHLORPYRIFOS USING CHROMOSOMAL BEHAVIOUR OF ROOT MERISTEM IN ALLIUM CEPA L.2024