Why the study?
Does systemic TLR9-stimulation upon onset of ischemia and reperfusion alter final infarct size in cardiac ischemia/reperfusion?
Does systemic TLR9-stimulation upon onset of ischemia and reperfusion alter final infarct size in cardiac ischemia/reperfusion?
Systemic TLR9 activation during cardiac ischemia/reperfusion does not reduce infarct size, questioning its potential clinical utility.
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TLR9 stimulation does not limit infarct size in this animal I/R model; hypothesis-generating and does not support clinical translation.
Systemic TLR9-stimulation upon onset of ischemia and subsequent reperfusion does not alter final infarct size despite causing clear alterations of both systemic and cardiac inflammatory parameters. Our results question the clinical usefulness of TLR9 activation during cardiac I/R.
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Ohm et al. (2014) studied this question.
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