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April 15, 2026Angewandte Chemie International Edition

Stereodefined Improbable 3Rotaxane by Post‐Interlocking Ring Editing

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Authors

CWCongsen WangDFDongsheng FuKWKai Wang

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Overview

This work demonstrates a new protocol to synthesize improbable rotaxanes, overcoming assembly challenges in the presence of chiral components.

Key Points

  • The aim is to develop a method for synthesizing improbable rotaxanes using a stereostable scaffold.
  • Utilized a covalent organic pillar COP-1 as the ring component, assembled by imine condensation.
  • Employed a threading-followed-by-stoppering protocol to produce enantiopure [2]rotaxanes.
  • Performed imine hydrolysis to edit the interlocked structures into improbably larger [3]rotaxanes.
  • Successfully created a mechanically interlocked structure with preserved stereochemical configuration.
  • Achieved chiral resolution in the assembly process without loss of enantiopurity.
  • Provided a new strategy which circumvents previous limitations in synthesizing multiring interlocked molecules.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69df2c77e4eeef8a2a6b18eehttps://doi.org/10.1002/anie.4543318
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