Population
27 patients with non-ischemic heart failure, and 12 rats.
Design
Preclinical
Authors
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Hypothesis-generating for lipotoxicity in metabolic non-ischemic HF; prospective studies needed before clinical consideration.
Intramyocardial lipid accumulation occurs in a subset of non-ischemic heart failure patients, particularly those with metabolic dysregulation, and is associated with gene expression changes linked to contractile dysfunction.
Sharma et al. (2004) studied this question.
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