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February 20, 2003Magnetic Resonance in MedicineOpen Access

Myocardial triglycerides and systolic function in humans: In vivo evaluation by localized proton spectroscopy and cardiac imaging

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Why the study?

Can proton magnetic resonance spectroscopy ((1)H MRS) accurately measure myocardial lipid content in vivo?

Population

Zucker rats (ex vivo) and 15 healthy humans (in vivo)

Comparison

Proton magnetic resonance spectroscopy ((1)H MRS) vs Biochemical measurement (in rat tissue)

Design

Other

Authors

LSLidia S. SzczepaniakVisionQuest Biomedical (United States)RDRobert L. DobbinsIndivior (United States)GMGregory J. MetzgerUniversity of Minnesota

Discussion

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Implication

May enable noninvasive myocardial steatosis assessment in obesity; leaves open its prognostic value and therapeutic targeting.

Structured PICO

Can proton magnetic resonance spectroscopy ((1)H MRS) accurately measure myocardial lipid content in vivo?

P
Population
Zucker rats (ex vivo) and 15 healthy humans (in vivo)
I
Intervention
Proton magnetic resonance spectroscopy ((1)H MRS)
C
Comparator
Biochemical measurement (in rat tissue)
O
Outcome
Myocardial triglyceride/lipid contentsurrogate

Proton magnetic resonance spectroscopy is a reproducible in vivo tool for measuring myocardial triglyceride content, which correlates with adiposity and changes in LV mass and function.

Cite This Study

Szczepaniak et al. (2003) studied this question.

synapsesocial.com/papers/69df484cacbf09c32e614803https://doi.org/10.1002/mrm.10372
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Simple Enzymatic Quantitative Analysis of Triglycerides in Tissues.1992 · 70 citations
  2. 2Role of Myocardial Inducible Nitric Oxide Synthase in Contractile Dysfunction and β-Adrenergic Hyporesponsiveness in Rats With Experimental Volume-Overload Heart Failure2002 · 91 citations
  3. 3Observation of cardiac lipids in humans by localized <sup>1</sup>H magnetic resonance spectroscopic imaging1994 · 81 citations
  4. 4Bulk magnetic susceptibility effects on the assessment of intra‐ and extramyocellular lipids in vivo2002 · 85 citations
  5. 5Pathology of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia—An Autopsy Study of 20 Forensic Cases1998 · 52 citations