Key result
Male gender shows no difference in myocardial triglyceride content versus females in healthy volunteers.
Why the study?
Myocardial triglyceride content is an accepted biomarker for chronic metabolic and cardiac disease, but potential gender-related differences in healthy individuals were unclear.
Does myocardial triglyceride content assessed by 1H-MRS differ between male and female healthy volunteers?
Cross-Sectional (n=40)
Does myocardial triglyceride content assessed by 1H-MRS differ between male and female healthy volunteers?
Absolute Event Rate: 0.28% vs 0.24%
Myocardial triglyceride content assessed by 1H-MRS does not significantly differ between healthy male and female individuals.
No sex difference in myocardial triglyceride content among healthy volunteers; leaves open potential sex-specific effects in disease states.
OBJECTIVE: Over the past decade, myocardial triglyceride content has become an accepted biomarker for chronic metabolic and cardiac disease. The purpose of this study was to use proton (hydrogen 1)-magnetic resonance spectroscopy ((1)H-MRS) at 3Tesla (3 T) field strength to assess potential gender-related differences in myocardial triglyceride content in healthy individuals. METHODS: Cardiac MR imaging was performed to enable accurate voxel placement and obtain functional and morphological information. Double triggered (i.e., ECG and respiratory motion gating) (1)H-MRS was used to quantify myocardial triglyceride levels for each gender. Two-sample t-test and Mann-Whitney U-test were used for statistical analyses. RESULTS: In total, 40 healthy volunteers (22 male, 18 female; aged >18 years and age matched) were included in the study. Median myocardial triglyceride content was 0.28% (interquartile range [IQR] 0.17-0.42%) in male and 0.24% (IQR 0.14-0.45%) in female participants, and no statistically significant difference was observed between the genders. Furthermore, no gender-specific difference in ejection fraction was observed, although on average, male participants presented with a higher mean ± SD left ventricular mass (136.3 ± 25.2 g) than female participants (103.9 ± 16.1 g). CONCLUSIONS: The study showed that (1)H-MRS is a capable, noninvasive tool for acquisition of myocardial triglyceride metabolites. Myocardial triglyceride concentration was shown to be unrelated to gender in this group of healthy volunteers.
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Petritsch et al. (2016) conducted a cross-sectional in Healthy (n=40). Male gender vs. Female gender was evaluated on Myocardial triglyceride content. Male gender was not associated with a significant difference in myocardial triglyceride content compared to female gender (median 0.28% vs 0.24%) in healthy volunteers.
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