Why the study?
Does specific activation of PAR-1 enhance vascular permeability in the rat hindpaw, and what is the role of nitric oxide in this process?
Population
Rat hindpaw model
Comparison
Intraplantar administration of the highly… vs Control/vehicle (implied) or baseline
Design
Preclinical
Authors
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Rat data on PAR-1 oedema should not change practice; leaves open human translation of NO modulation.
Does specific activation of PAR-1 enhance vascular permeability in the rat hindpaw, and what is the role of nitric oxide in this process?
Specific activation of PAR-1 increases vascular permeability via mast cell degranulation, an inflammatory effect that is suppressed by endogenous and exogenous nitric oxide.
Kawabata et al. (1999) studied this question.
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