Why the study?
Does inhibition of nitric oxide production modulate vascular permeability in the coronary circulation in conscious rats?
Population
Conscious rats
Comparison
Intravenous injection of NG-nitro-L-arginine… vs Noradrenaline infusion to match blood pressure
Design
Preclinical
Authors
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Does not support clinical use of NO modulators; leaves open translation of rat coronary permeability effects to human disease.
Does inhibition of nitric oxide production modulate vascular permeability in the coronary circulation in conscious rats?
Inhibition of endogenous NO synthesis increases protein extravasation and potentiates the permeability effects of PAF and endothelin-1 in the rat coronary circulation, suggesting NO regulates vascular permeability.
Filep et al. (1993) studied this question.
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