Why the study?
Do nitric oxide synthase inhibitors alter microvessel permeability and endothelial cell [Ca2+]i in frog mesenteric venular microvessels?
Do nitric oxide synthase inhibitors alter microvessel permeability and endothelial cell [Ca2+]i in frog mesenteric venular microvessels?
Basal levels of nitric oxide play a role in modulating microvessel permeability, potentially acting as an antioxidant, independent of changes in endothelial cell calcium.
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Suggests basal NO modulates permeability independently of Ca2+; leaves open relevance to human microvascular disease.
He et al. (1997) studied this question.
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