Why the study?
Does endogenous nitric oxide modulate PAF-induced microvascular albumin leakage and hypotension in conscious rats?
Population
Conscious rats
Comparison
NG-nitro-L-arginine methyl ester with or without… vs Noradrenaline infusion to maintain mean arterial…
Design
Preclinical
Follow-up
15 minutes
Authors
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Endogenous NO appears to regulate vascular permeability separately from hypotension in rats; leaves open applicability to clinical PAF syndromes.
Does endogenous nitric oxide modulate PAF-induced microvascular albumin leakage and hypotension in conscious rats?
Endogenous nitric oxide plays an important role in regulating albumin extravasation and modulating the vascular permeability effect of PAF in conscious rats, independent of its hypotensive action.
Filep et al. (1993) studied this question.
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