Why the study?
Does L-NAME reduce PAF-induced microvascular leakage in Sprague-Dawley rats?
Population
Sprague-Dawley rats (n=9)
Comparison
NG-nitro-L-arginine methyl ester 10 mg/kg… vs Normal saline solution intravenously 1 hour…
Design
Preclinical
Authors
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L-NAME attenuates PAF-induced leakage in rat airways; leaves open clinical translation of NOS inhibition.
Does L-NAME reduce PAF-induced microvascular leakage in Sprague-Dawley rats?
Inhibition of nitric oxide synthase with L-NAME significantly reduces PAF-induced microvascular leakage in rat airways, suggesting endogenous NO mediates this process.
Jeon et al. (2001) studied this question.
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