Why the study?
Does urinary kallikrein excretion predict blood pressure response to ACE inhibitors and calcium antagonists in hypertensive patients?
Does urinary kallikrein excretion predict blood pressure response to ACE inhibitors and calcium antagonists in hypertensive patients?
Urinary kallikrein activity may serve as a biomarker to predict the blood pressure response to ACE inhibitors and calcium antagonists in hypertensive patients.
Hypothesis-generating for urinary kallikrein as response predictor; leaves open need for prospective validation before clinical use.
Our data indicate that urinary kallikrein activity may represent an index to predict the chronic antihypertensive effect not only of ACE inhibition but also of calcium antagonism, and support the concept that the renal kallikrein-kinin system might play some contributory role in modulating the hypotensive action of ACE inhibitors.
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-Fulgheri et al. (1993) studied this question.
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