Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 16, 2026Biomolecules and BiomedicineOpen Access

Survival outcomes and prognostic nomogram for primary pulmonary MALT lymphoma and diffuse large B-cell lymphoma: A SEER database study

View Full Paper
Ask AI
Bookmark
Share

Key result

Primary pulmonary MALT lymphoma is linked to ~63 months longer median overall survival than DLBCL.

  • P<0.001
  • n=2,343

Why the study?

Primary pulmonary lymphoma is a rare extranodal malignancy with limited population-based evidence regarding treatment and outcomes.

Does primary pulmonary MALT lymphoma have better survival outcomes compared to primary pulmonary DLBCL?

Population

2,343 patients with primary pulmonary MALT lymphoma or DLBCL from the SEER database

Comparison

Primary pulmonary MALT lymphoma vs primary pulmonary DLBCL

Design

Retrospective propensity score-matched registry-based study

Authors

JLJun LiHubei University of MedicineYFYuan FengHZHuaying ZhangHubei University of Medicine

Discussion

Loading...

Member takes

Implication

Histologic subtype should guide prognosis in primary pulmonary lymphoma; confirms its independent prognostic role.

Key Points

  • The aim is to compare survival outcomes and treatment patterns between MALT lymphoma and DLBCL, and to develop a prognostic model for DLBCL.
  • Identified patients from the SEER database diagnosed between 2010 and 2022.
  • Used propensity score matching to analyze survival outcomes.
  • Employed Kaplan-Meier analysis and Cox regression for statistical assessment.
  • Developed and validated a nomogram for predicting DLBCL survival.
  • MALT lymphoma showed significantly better overall survival compared to DLBCL (131 months vs. 68 months).
  • Age ≥60 years was identified as an adverse prognostic factor for DLBCL.
  • Surgical intervention and chemotherapy improved overall and cancer-specific survival.
  • The nomogram effectively predicted 1-, 3-, and 5-year survival with moderate accuracy.

Study Design

Type

Observational (n=2,343)

Multicenter

Yes

Structured PICO

Does primary pulmonary MALT lymphoma have better survival outcomes compared to primary pulmonary DLBCL?

P
Population
2,343 patients with primary pulmonary lymphoma (1,427 MALT lymphoma and 916 DLBCL) diagnosed between 2010 and 2022 from the SEER database.
I
Intervention
Primary pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma
C
Comparator
Primary pulmonary diffuse large B-cell lymphoma (DLBCL)
O
Outcome
Overall survival (OS) and cancer-specific survival (CSS)hard clinical

Main Result

Absolute Event Rate: 131% vs 68%

p-value: p=<0.001

Histological subtype is a critical determinant of prognosis in primary pulmonary lymphoma, with MALT lymphoma showing significantly better survival than DLBCL.

Limitations

  • SEER database lacks specific chemotherapy agents, radiation doses, and molecular pathological indicators
  • PSM unable to balance patient performance status and comorbidities
  • Loss of samples during matching
  • Lack of comprehensive details regarding treatment sequences or lines
  • Potential inclusion of systemic lymphoma with secondary pulmonary involvement

Cite This Study

Li et al. (2026) conducted an observational in Primary pulmonary lymphoma (MALT lymphoma and DLBCL) (n=2,343). Primary pulmonary MALT lymphoma vs. Primary pulmonary DLBCL was evaluated on Median overall survival (months) (p=<0.001). Primary pulmonary MALT lymphoma was significantly associated with better overall survival compared to primary pulmonary DLBCL, with a median overall survival of 131 months versus 68 months.

synapsesocial.com/papers/69e07de52f7e8953b7cbed6chttps://doi.org/10.17305/bb.2026.13944
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Letter regarding “Survival outcomes and prognostic nomogram for primary pulmonary MALT lymphoma and diffuse large B-cell lymphoma: A SEER database study”2026
  2. 2Role of Surgical Therapy in Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma and Development of a Survival Nomogram2026
  3. 3Prognostic factors and predictive models for primary pulmonary diffuse large B-cell lymphoma: a population-based analysis2024 · 1 citations
  4. 4Prognostic factors and nomogram for survival prediction in patients with primary pulmonary lymphoma: a SEER population-based study2019 · 20 citations
  5. 5Clinical characteristics, diagnosis, treatment, and prognostic factors of pulmonary mucosa‐associated lymphoid tissue‐derived lymphoma2019 · 43 citations