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August 22, 2026Annals of Surgical OncologyOpen Access

Role of Surgical Therapy in Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma and Development of a Survival Nomogram

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Authors

KWKe WangDYDeyu YangZLZhichao Li

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Overview

Retrospective database study demonstrates surgical resection improves overall survival in pulmonary MALT lymphoma, suggesting surgery provides strong prognostic benefits.

Key Points

  • To examine clinical characteristics, prognostic determinants, and therapeutic outcomes in pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma, and to construct a predictive survival nomogram.
  • Queried the Surveillance, Epidemiology, and End Results (SEER) registry for patients diagnosed with pulmonary MALT lymphoma between 2000 and 2020 (N=1,721).
  • Compared survival across stages and treatment modalities, identifying independent prognostic factors using multifactorial Cox regression analysis.
  • Developed and calibrated a nomogram to predict 3-, 5-, and 10-year overall survival (OS).
  • In stages I and II disease, patients undergoing surgical resection showed superior survival trends compared to those treated with radiotherapy.
  • Multifactorial Cox regression identified male sex, older age, advanced Ann Arbor stage, and lack of surgery as significant adverse prognostic factors for OS.
  • The predictive nomogram achieved a concordance index (C-index) of 0.718, with area under the curve (AUC) values of 0.7235 at 3 years, 0.7328 at 5 years, and 0.7917 at 10 years.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a895f9cca7ade938187e4e5https://doi.org/10.1245/s10434-026-20313-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical characteristics, diagnosis, treatment, and prognostic factors of pulmonary mucosa‐associated lymphoid tissue‐derived lymphoma2019 · 43 citations
  2. 2Clinical Features and Survival Outcome of Early-Stage Primary Pulmonary MALT Lymphoma After Surgical Treatment2021 · 4 citations
  3. 3Comparisons of Surgery and/or Chemotherapy in the Treatment of Primary Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma2014 · 11 citations
  4. 4Survival outcomes and prognostic nomogram for primary pulmonary MALT lymphoma and diffuse large B-cell lymphoma: A SEER database study2026
  5. 5Pulmonary mucosa-associated lymphoid tissue lymphoma: insights from a 15-year study at a single institution involving 14 clinical cases2024 · 5 citations