AVC may flag subclinical CAD in aging patients with risk factors; leaves open progression mechanisms and intervention targets.
In the population, AVC is frequent with aging and atherosclerotic risk factors. AVC is a marker of subclinical CAD. AVC is progressive, appearing de novo with progressive atherosclerosis whereas established AVC progresses independently of atherosclerotic risk factors and faster with increasing initial AVC loads.
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Messika‐Zeitoun et al. (2006) studied this question.
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