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April 17, 2026CancersOpen Access

Liver Transplantation as a Salvage Therapy Option in Colorectal Liver Metastases: Feasibility, Oncologic Outcomes, and Survival After Failure of Conventional Therapy—A Systematic Review and Meta-Analysis

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Authors

FSFaiza H SoomroCollaborative Group (United States)TKTehreem KazmiDivisional Headquarters Teaching Hospital MirpurMAMehwish AnsarShrewsbury and Telford Hospital NHS Trust

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Implication

Systematic review reveals beneficial survival outcomes in patients with unresectable colorectal liver metastases post conventional treatment failure, indicating a viable option.

Key Points

  • To evaluate the feasibility and long-term survival outcomes of liver transplantation in patients with unresectable colorectal liver metastases after conventional therapy failure.
  • Conducted systematic review following PRISMA 2020 guidelines
  • Searched electronic databases for studies from November 2015 to November 2025
  • Performed random-effect meta-analyses for survival and recurrence rates
  • Assessed heterogeneity using I2 statistics
  • Pooled overall survival was 96.6% at 1 year, 73.4% at 3 years, and 49.4% at 5 years post-transplantation
  • Pooled recurrence rate was 63.5%, with extrahepatic recurrence being common, especially in the lungs
  • Disease-free survival was reported at 64.1%, with high heterogeneity
  • Biological risk factors significantly influenced survival outcomes

Cite This Study

Soomro et al. (2026) studied this question.

synapsesocial.com/papers/69e1ce3b5cdc762e9d857589https://doi.org/10.3390/cancers18081254
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Liver Transplantation for Unresectable Colorectal Liver Metastases2025 · 6 citations
  2. 2Intensive locoregional therapy before liver transplantation for colorectal cancer liver metastasis: A novel pretransplant protocol2024 · 30 citations
  3. 3Actual 10-Year Survival After Resection of Colorectal Liver Metastases Defines Cure2007 · 1,193 citations
  4. 4Colorectal cancer liver metastases – a population-based study on incidence, management and survival2018 · 922 citations
  5. 5Liver Transplantation for Non‐Resectable Liver Metastases from Colorectal Cancer: A Systematic Review and Meta‐Analysis2021 · 24 citations