What question did this study set out to answer?

The study aims to review literature and conduct a meta-analysis on the relationship between dMPA exposure and cerebral meningioma diagnosis.

April 17, 2026CancersOpen Access

A Systematic Review and Meta-Analysis of the Association Between Depot Medroxyprogesterone Acetate and Cerebral Meningioma

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Authors

LRLindy ReynoldsUniversity of Alabama at Birmingham RARebecca C. ArendUniversity of Alabama at Birmingham RGRussell L. Griffin

Discussion

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Implication

Systematic review uncovers increased odds of cerebral meningioma with depot medroxyprogesterone acetate exposure, indicating a need for patient discussions regarding risks.

Key Points

The study aims to review literature and conduct a meta-analysis on the relationship between dMPA exposure and cerebral meningioma diagnosis.
Conducted a systematic review and meta-analysis of observational studies.
Searched PubMed, Web of Science, and Embase databases for relevant studies.
Calculated odds ratios (ORs) and 95% confidence intervals (CIs) for dMPA effects.
Assess quality of evidence using GRADE methodology.
Analyzed nine case-control studies and one cohort study.
Overall pooled OR for dMPA exposure linked to meningioma was 2.78 (95% CI 2.20–3.52).
Stronger association observed with prolonged dMPA exposure (≥two years, OR 3.49, 95% CI 2.35–5.18).
GRADE analysis indicated a moderate quality of evidence.

Cite This Study

Reynolds et al. (2026) studied this question.

synapsesocial.com/papers/69e1d0165cdc762e9d8591d1 https://doi.org/10.3390/cancers18081252

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Implication

Systematic review uncovers increased odds of cerebral meningioma with depot medroxyprogesterone acetate exposure, indicating a need for patient discussions regarding risks.

A Systematic Review and Meta-Analysis of the Association Between Depot Medroxyprogesterone Acetate and Cerebral Meningioma

Discussion

Member takes

Implication

Key Points

Cite This Study

A Systematic Review and Meta-Analysis of the Association Between Depot Medroxyprogesterone Acetate and Cerebral Meningioma

Discussion

Member takes

Implication

Key Points

Cite This Study

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