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April 18, 2026ACS Sensors

Biological Optical Nanocavity-Coupled Electrochemiluminescence Sensor for the Detection of Extracellular Vesicle Glycosylation in Gastric Cancer Diagnosis

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Authors

PWPeilin WangZLZhenrun LiWLWenyan Li

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Overview

An electrochemiluminescence sensor reveals glycoprotein distribution in extracellular vesicles, indicating potential for gastric cancer diagnosis.

Key Points

  • This research aims to develop a sensor that detects glycosylation patterns in extracellular vesicles related to gastric cancer.
  • Developed an electrochemiluminescence sensor coupled with a biological optical nanocavity.
  • Used curvature-sensitive peptide probes for region-specific recognition of EVs.
  • Constructed plasmonic effects by assembling gold nanoparticles on EV membranes.
  • Achieved a detection limit of 3.2 × 10³ particles mL⁻¹ for EVs.
  • Diagnostic accuracy of 95% for detecting peritoneal metastasis in gastric cancer.
  • Identified preferential distribution of MUC1 with terminal sialylation in high curvature EV regions.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69e3211640886becb6540402https://doi.org/10.1021/acssensors.6c00361
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  5. 5Development of a Sensitive Electrochemical Aptasensor for Non‐Small Cell Lung Cancer Extracellular Vesicle Detection2025