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April 18, 2026HaemophiliaOpen Access

Rare Bleeding Disorders and Bleeding Disorder of Unknown Cause: Current Understanding and Recent Developments

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Authors

ACAlessandro CasiniRKRobert KlamrothBHBauke Haisma

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Overview

State-of-the-art review explores bleeding disorders, their management challenges, and diagnostic advancements.

Key Points

  • This review aims to summarize recent developments in rare bleeding disorders and bleeding disorders of unknown cause.
  • Utilized a State-of-the-Art review format
  • Focused on four representative conditions: IPFDs, fibrinogen disorders, FXI deficiency, and BDUC
  • Evaluated management challenges and diagnostic approaches
  • Identified variability in bleeding severity and the need for specialized care in IPFDs
  • Noted limited assay availability affecting fibrinogen disorders management
  • Highlighted weak association between factor levels and bleeding phenotype in FXI deficiency
  • Showed overlaps between BDUC and mild inherited disorders

Cite This Study

Casini et al. (2026) studied this question.

synapsesocial.com/papers/69e3211640886becb654049ahttps://doi.org/10.1111/hae.70278
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Also Consider

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  1. 1How I Investigate Bleeding Disorders of Unknown Cause: Current Diagnostic Pathways and Gaps in Laboratory Investigation2026
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  4. 4Diagnosis of bleeding disorder of unknown cause: how many tests are enough to diagnose BDUC?2025
  5. 5How to treat patients with bleeding disorder of unknown cause?2024 · 5 citations