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July 10, 2026International Journal of Laboratory HematologyOpen Access

How I Investigate Bleeding Disorders of Unknown Cause: Current Diagnostic Pathways and Gaps in Laboratory Investigation

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Authors

DMDino MehicFKFaris KaraselimovicTDTim Dreier

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Overview

Randomized trial explores diagnostic pathways for bleeding disorders in patients, indicating significant gaps in current laboratory investigations.

Key Points

  • This research aims to identify diagnostic challenges and effective pathways for evaluating bleeding disorders of unknown cause.
  • Examination of clinical bleeding phenotypes and associated factors.
  • Systematic exclusion of known bleeding disorders such as coagulation factor deficiencies and von Willebrand disease.
  • Analysis of diagnostic tests and their limitations in identifying rare causes.
  • Identified substantial diagnostic overlap between BDUC and other bleeding disorders.
  • Highlighted the inadequacy of routine assays to detect clinically relevant factor deficiencies.
  • Emphasized the need for further investigation into rare causes of bleeding in specific phenotypes.

Cite This Study

Mehic et al. (2026) studied this question.

synapsesocial.com/papers/6a508d096eeac72a437a0ce8https://doi.org/10.1111/ijlh.70191
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Also Consider

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