The Frank-Starling mechanism remains intact in end-stage human heart failure despite significant alterations in diastolic myocardial distensibility.
Preserved Frank-Starling in end-stage HF supports preload assessment; leaves open diastolic mechanisms for targeted study.
The Frank-Starling mechanism is maintained in end-stage failing human hearts, whereas significant alterations of diastolic myocardial distensibility are evident in chronic heart failure.
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Holubarsch et al. (1996) studied this question.
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