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April 19, 2026Frontiers in NeurologyOpen Access

Gut microbiota dynamics and its impact on the efficacy of ACTH therapy in infantile epileptic spasms syndrome

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Authors

XZXi ZhangGeneral CardiologyXHX M HuJilin UniversityXHXiaosheng Hao

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Implication

This preliminary study investigates gut microbiota's role as a biomarker for ACTH therapy response in infantile epileptic spasms syndrome, implying potential treatment pathways.

Key Points

  • This study aims to explore the relationship between gut microbiota composition and response to ACTH therapy in pediatric patients with infantile epileptic spasms syndrome.
  • Enrolled eighteen patients with infantile epileptic spasms syndrome and two control groups (focal epilepsy and healthy).
  • Categorized patients into ACTH-effective and ACTH-ineffective groups based on treatment response.
  • Collected fecal samples pre-and post-ACTH treatment for 16S ribosomal DNA sequencing and bioinformatics analysis.
  • Notable differences in gut microbiota α-diversity and β-diversity among IESS, FE, and H groups.
  • Increased levels of Proteobacteria and Actinobacteria in IESS compared to FE and H groups.
  • Before treatment, ACTH-ineffective subgroup had lower abundance of actinomycetes and bifidobacteria, correlated with weaker network aggregation.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69e470a4010ef96374d8d813https://doi.org/10.3389/fneur.2026.1804171
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification of adrenocorticotropic hormone–specific therapeutic biomarkers in infantile epileptic spasm syndrome using data-independent acquisition mass spectrometry2025
  2. 2Factors influencing efficacy and relapse of adrenocorticotropic hormone in infantile epileptic spasms syndrome2024 · 4 citations
  3. 3Analysis of treatment outcome variations in infantile epileptic spasms syndrome2026
  4. 4Treatment history as early indicators of short-term response to ACTH therapy in infantile epileptic spasms syndrome: a propensity score matching analysis2026
  5. 5Efficacy of synthetic ACTH in confirmed and presumed monogenic developmental and epileptic encephalopathies2026