Multisite Spinal Cord and Canal Morphometry Reveals Age-Linked and Sex-Linked Structural Vulnerability in Degenerative Cervical Myelopathy Outcomes

Zachary A. Smith; Grace Haynes; Sandrine Bédard; Sanaa Hameed; Ali F. Khan; Amber Dastgir; Alaa Baha; Umesh Kumar; Michael Van Hal; Mazin Al Tamimi; Serena S. Hu; Yasin Dhaher; Hakeem J. Shakir; John Ratliff; Kenneth A. Weber; Muhammad Fauziyya

doi:10.1227/neu.0000000000004050

April 17, 2026NeurosurgeryOpen Access

Multisite Spinal Cord and Canal Morphometry Reveals Age-Linked and Sex-Linked Structural Vulnerability in Degenerative Cervical Myelopathy Outcomes

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Key Points

The research aims to explore how age and sex influence the structural features of the spinal cord in degenerative cervical myelopathy (DCM).
Utilized automated spinal cord morphometry across multiple sites.
Analyzed morphometric data based on age and sex dependencies.
Identified anatomical differences relevant to DCM outcomes.
Found significant age-dependent structural variations in the spinal cord related to DCM.
Revealed sex-specific morphological changes impacting surgical outcomes.
Established individualized biomarkers for monitoring DCM progression.

Implication

Automated morphometry identifies age and sex differences in cervical myelopathy outcomes, suggesting personalized risk assessment.

Abstract

Automated SC morphometry reveals key age-dependent and sex-dependent differences in DCM. Age-based and sex-based morphometrics offer anatomically specific and individualized biomarkers for risk stratification, progression monitoring, and surgical outcome prediction.

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Cite This Study

Smith et al. (2026) studied this question.

synapsesocial.com/papers/69e473de010ef96374d8f985 https://doi.org/10.1227/neu.0000000000004050

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Multisite Spinal Cord and Canal Morphometry Reveals Age-Linked and Sex-Linked Structural Vulnerability in Degenerative Cervical Myelopathy Outcomes

Key Points

Implication

Abstract

Discussion

Cite This Study

Multisite Spinal Cord and Canal Morphometry Reveals Age-Linked and Sex-Linked Structural Vulnerability in Degenerative Cervical Myelopathy Outcomes

Key Points

Implication

Abstract

Discussion

Cite This Study

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