EXPRESS: Reversible Congestive Heart Failure Associated With Diabetes Mellitus in Two Cats

Title Reversible Congestive Heart Failure Associated With Diabetes Mellitus in Two Cats Case series summary This report describes two cats diagnosed with diabetes mellitus that developed clinical signs consistent with congestive heart failure (CHF). Clinical and echocardiographic findings improved over time with stabilisation and optimisation of glycaemic management. Both cats presented with dyspnea, hypotension and hypothermia. Thoracic radiographs demonstrated diffuse pulmonary infiltrates. Pleural effusion was identified in one case. Echocardiography revealed left ventricular thickening with left atrial enlargement. Laboratory abnormalities included hyperglycaemia, elevated fructosamine and increased N-terminal pro–B-type natriuretic peptide (NT-proBNP) concentrations. Following CHF therapy and insulin administration, both cats showed rapid clinical improvement, with NT-proBNP concentrations decreasing into the reference range and improvement in echocardiographic parameters within weeks. One cat later showed again an increase in myocardial thickness and experienced recurrence of CHF during a period of poor glycaemic control, with subsequent improvement following intensified glycaemic management. Relevance and novel information To the authors’ knowledge, this is the first report describing cats diagnosed with diabetes mellitus that developed congestive heart failure accompanied by increased left ventricular wall thickness and left atrial enlargement on echocardiography, with subsequent improvement following clinical stabilisation and glycaemic management. These cases suggest a potential association between metabolic dysregulation and the occurrence of congestive heart failure in cats. Keywords congestive heart failure; diabetes mellitus; echocardiography; glycaemic management