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April 24, 2026Precision NanomedicineOpen Access

Nanoemulsion omega-3 reduces fibrosis and improves diastolic function vs conventional omega-3 in murine HFpEF.

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Why the study?

Clinical efficacy of omega-3 fatty acids remains inconsistent, potentially due to limited tissue bioavailability, while myocardial incorporation may be essential for reversing structural damage in heart failure.

Does nanoemulsion-based delivery of omega-3 fatty acids improve cardiac uptake and functional outcomes in a murine HFpEF model compared to conventional omega-3 oil?

Population

C57BL/6J mice with diet- and L-NAME-induced HFpEF

Comparison

Nanoformulation NG-Omega-3 vs conventional omega-3 oil

Design

Preclinical animal study

Follow-up

10 weeks

Key result

Nanoemulsion-formulated omega-3 fatty acids increased myocardial accumulation, reduced fibrosis, and improved diastolic function compared to conventional omega-3 in a murine HFpEF model.

Authors

KFKati FridYRYair RokachOBOrli Binyamin

Discussion

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Member takes

Overview

Hypothesis-generating for nanoemulsion omega-3 in HFpEF; leaves open clinical translation pending human trials.

Key Points

  • The central aim is to evaluate if nanoemulsion enhances cardiac uptake of omega-3 fatty acids and improves outcomes in heart failure.
  • Mice received conventional omega-3 oil or NG-Omega-3 via oral gavage.
  • Heart failure was induced in mice through a high-fat diet and L-NAME administration for 10 weeks.
  • Cardiac function was assessed by echocardiography, while fibrosis and immune-cell infiltration were evaluated histologically.
  • NG-Omega-3 significantly increased myocardial accumulation of omega-3 fatty acids, especially EPA.
  • NG-Omega-3 reduced left ventricular wall thickening and improved diastolic indexes and global longitudinal strain.
  • Both formulations decreased CD4⁺ immune-cell infiltration in cardiac tissue.

Structured PICO

Does nanoemulsion-based delivery of omega-3 fatty acids improve cardiac uptake and functional outcomes in a murine HFpEF model compared to conventional omega-3 oil?

P
Population
C57BL/6J mice with heart failure with preserved ejection fraction (HFpEF) induced by high-fat diet combined with nitro-L-arginine methyl ester (L-NAME) administration
I
Intervention
Self-emulsifying nanoformulation of omega-3 fatty acids (NG Omega-3) via oral gavage for 10 weeks
C
Comparator
Conventional omega-3 oil via oral gavage
O
Outcome
Myocardial accumulation of omega-3 fatty acids, cardiac function (echocardiography and strain analysis), myocardial fibrosis, and immune-cell infiltrationsurrogate

Nanoemulsion delivery enhances myocardial bioavailability of omega-3 fatty acids and improves structural remodeling and diastolic function in a murine HFpEF model.

Cite This Study

Frid et al. (2026) studied this question. Nanoemulsion-formulated omega-3 fatty acids increased myocardial accumulation, reduced fibrosis, and improved diastolic function compared to conventional omega-3 in a murine HFpEF model.

synapsesocial.com/papers/69eb0a66553a5433e34b482chttps://doi.org/10.33218/001c.161077
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