Why the study?
Do omega-3 fatty acids prevent pressure overload-induced cardiac fibrosis in mice?
Population
Mice subjected to transverse aortic constriction and isolated adult mouse cardiac fibroblasts
Comparison
Dietary supplementation with fish oil vs Control diet
Design
Preclinical
Follow-up
4 weeks
Authors
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Should not yet change practice; hypothesis-generating for omega-3 effects on pressure-overload fibrosis in humans.
Do omega-3 fatty acids prevent pressure overload-induced cardiac fibrosis in mice?
Omega-3 fatty acids prevent cardiac fibrosis and dysfunction in a mouse model of pressure overload by activating the cGMP/PKG pathway in cardiac fibroblasts.
Chen et al. (2011) studied this question.
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