Key result
Antioxidant vitamins prevent high-fat meal-induced cytokine and adhesion molecule spikes in healthy and diabetic subjects.
Why the study?
The postprandial state is increasingly recognized to affect early atherogenesis, prompting evaluation of how high-fat and high-carbohydrate meals, with and without antioxidant vitamins, impact endothelial activation.
Population
20 newly diagnosed type 2 diabetic patients and 20 age- and gender-matched healthy subjects
Comparison
High-fat meal vs high-carbohydrate meal, with and without antioxidant vitamins
Design
Randomized, observer-blinded crossover study
Authors
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Should not yet change practice in diabetes; leaves open CV benefit of blunting postprandial inflammation with antioxidants.
RCT (n=40)
Observer-blinded
Randomized
Nappo et al. (2002) conducted an RCT in Type 2 diabetes mellitus and healthy subjects (n=40). High-fat meal and high-carbohydrate meal with or without antioxidant vitamins vs. Crossover was evaluated on Plasma levels of TNF-alpha, IL-6, ICAM-1 and VCAM-1. A high-fat meal increased cytokines and adhesion molecules in both healthy and diabetic subjects, which was prevented by antioxidant vitamins, with changes in triglycerides linked to TNF-alpha (p<0.01).
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