In Vivo Validation of a Novel Computational Approach to Assess Microcirculatory Resistance Based on a Single Angiographic View
Why the study?
Despite the clinical value of the index of microvascular resistance (IMR) for assessing coronary microcirculation, its global use remains very low.
Does the angiographic microvascular resistance (AMR) index accurately assess coronary microvascular dysfunction compared to invasive wire-based IMR in patients undergoing coronary angiography?
Comparison
Novel single-view AMR index vs invasive wire-based IMR reference standard
Design
Blinded diagnostic validation study
Authors
Discussion
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Member takes
Implication
AMR may support wire-free microvascular assessment during angiography; leaves open need for outcome trials before clinical adoption.
Structured PICO
Does the angiographic microvascular resistance (AMR) index accurately assess coronary microvascular dysfunction compared to invasive wire-based IMR in patients undergoing coronary angiography?
P
Population
163 patients (257 vessels) undergoing diagnostic coronary angiography and investigated with pressure wire-based IMR
I
Intervention
Angiographic microvascular resistance (AMR) index computed from a single angiographic view (pressure-wire- and adenosine-free)
C
Comparator
Invasive pressure wire-based index of microvascular resistance (IMR)
O
Outcome
Diagnostic performance of AMR compared with wire-based IMR (using IMR ≥ 25 as reference for microvascular dysfunction)surrogate
AMR derived from a single angiographic view provides a highly accurate, wire-free, and adenosine-free alternative to invasive IMR for assessing coronary microvascular dysfunction.
Cite This Study
Fan et al. (2022) studied this question.