Why the study?
Does chronic high blood flow increase NOS3 mRNA and protein expression in rat aorta?
Population
21 rats (12 with arteriovenous fistulas and 9 sham-operated controls)
Comparison
Chronic high blood flow induced by arteriovenous… vs Sham-operated control rats
Design
Preclinical
Authors
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No immediate clinical implications; leaves open translation of flow-mediated NOS3 upregulation to human vascular disease.
Does chronic high blood flow increase NOS3 mRNA and protein expression in rat aorta?
Chronic high blood flow in vivo significantly upregulates endothelial nitric oxide synthase (NOS3) mRNA and protein expression, as well as NOS activity, in rat aortas.
Nadaud et al. (1996) studied this question.
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