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July 1, 1993Proceedings of the National Academy of SciencesOpen Access

Regulation of endothelin 1 gene by fluid shear stress is transcriptionally mediated and independent of protein kinase C and cAMP.

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Population

Bovine aortic endothelial cells

Design

Preclinical

Authors

AMAdel M. MalekTufts UniversityAGAmelia GreeneUniversity of Kansas Medical CenterSISeigo IzumoHeart Failure & Transplant

Discussion

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Implication

Provides mechanistic insight into ET-1 regulation by shear stress; leaves open clinical relevance in cardiovascular disease.

Structured PICO

P
Population
Bovine aortic endothelial cells
I
Intervention
Fluid shear stress (20 dynes/cm2)
O
Outcome
ET-1 mRNA levels and peptide releasesurrogate

Fluid shear stress down-regulates endothelin-1 gene transcription in endothelial cells through a distinct mechanism independent of PKC and cAMP pathways.

Cite This Study

Malek et al. (1993) studied this question.

synapsesocial.com/papers/6a1bf0bcd54006be995f43c8https://doi.org/10.1073/pnas.90.13.5999
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Flow-induced changes in Ca2+ signaling of vascular endothelial cells: effect of shear stress and ATP1991 · 175 citations
  2. 2The Human Preproendothelin-1 Gene1989 · 442 citations
  3. 3Differential activation of protein kinase C alpha is associated with arachidonate release in Madin-Darby canine kidney cells.1990 · 86 citations
  4. 4Adaptive regulation of wall shear stress to flow change in the canine carotid artery1980 · 826 citations
  5. 5The mitogenic signaling pathway but not the plasminogen activator-inducing pathway of basic fibroblast growth factor is mediated through protein kinase C in fetal bovine aortic endothelial cells.1989 · 132 citations