Population
Primary cultures of human umbilical vein endothelial cells (HUVEC)
Comparison
Laminar shear stress of 1, 15 or 30 dyn cm-2… vs Static control
Design
Preclinical
Follow-up
24 hours
Authors
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May explain vasoprotective effects of laminar flow; hypothesis-generating for endothelin modulation in cardiovascular disease.
Arterial laminar shear stress downregulates endothelin synthesis and upregulates the ETB receptor in human endothelial cells, suggesting a mechanism for its vasoprotective effects.
Morawietz et al. (2000) studied this question.
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