Why the study?
Does nesiritide increase the risk of worsening renal function in patients with acutely decompensated heart failure?
Does nesiritide increase the risk of worsening renal function in patients with acutely decompensated heart failure?
Nesiritide is associated with a significantly increased risk of worsening renal function in patients with acutely decompensated heart failure.
Caution against nesiritide in ADHF; confirms renal harm in this RCT.
Nesiritide significantly increases the risk of worsening renal function in patients with ADHF. Whether worsening renal function reflects hemodynamic effect or renal injury is unknown, but the prognostic importance of worsening renal function suggests the need for further investigation in appropriately powered clinical trials.
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Sackner‐Bernstein et al. (2005) studied this question.
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