Why the study?
Do admission BUN and changes in renal function predict postdischarge survival in patients hospitalized for worsening heart failure, and does milrinone improve outcomes in this group?
Do admission BUN and changes in renal function predict postdischarge survival in patients hospitalized for worsening heart failure, and does milrinone improve outcomes in this group?
Elevated admission BUN and worsening renal function during hospitalization for heart failure predict worse survival, and milrinone therapy does not improve outcomes in this high-risk population.
BUN trends identify high-risk HF patients; this observational link leaves open whether targeted therapies alter survival.
A substantial number of patients admitted with heart failure have worsening renal function during hospitalization. Higher admission BUN and increasing BUN during hospitalization, independently of admission values, are associated with a worse survival rate. Use of milrinone in these high-risk patients does not improve outcomes despite minor improvements in the renal function.
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Klein et al. (2008) studied this question.
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