Renal Function as a Predictor of Outcome in a Broad Spectrum of Patients With Heart Failure
Why the study?
Does impaired renal function predict adverse outcomes in patients with heart failure, and does baseline eGFR modify the beneficial effect of candesartan?
Population
Patients with congestive heart failure (CHF) with both preserved as well as reduced LVEF
Design
Cohort
Authors
Discussion
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Member takes
Implication
Renal impairment aids HF risk stratification across LVEF; leaves open whether eGFR should guide candesartan use in prospective trials.
Structured PICO
Does impaired renal function predict adverse outcomes in patients with heart failure, and does baseline eGFR modify the beneficial effect of candesartan?
P
Population
Patients with congestive heart failure (CHF) with both preserved as well as reduced LVEF
I
Intervention
Candesartan
O
Outcome
Death, cardiovascular death, and hospitalization for heart failurehard clinical
Impaired renal function is a strong independent predictor of adverse outcomes in heart failure across the LVEF spectrum, but does not diminish the therapeutic benefit of candesartan.
Cite This Study
Hillege et al. (2006) studied this question.