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February 1, 1995Journal of Clinical InvestigationOpen Access

Differential regulation of two types of intracellular calcium release channels during end-stage heart failure.

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Key Points

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Authors

LGLoewe O. GoCardiovascular Institute of the South MMMaria C. MoschellaIcahn School of Medicine at Mount Sinai JWJ WatrasUniversity of Connecticut

Discussion

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Implication

Opposite RyR/IP3R regulation in failing myocardium may impair contractility; leaves open causal role and therapeutic targeting.

Cite This Study

Go et al. (1995) studied this question.

synapsesocial.com/papers/69eedfafa84321e0ae63c87b https://doi.org/10.1172/jci117739

Topics

Heart transplantation Heart failure HFrEF treatment Cardiomyopathy

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Also Consider

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