September 11, 2024JACC. Cardiovascular imaging17 citationsOpen Access
View Full PaperCoronary Microvascular Function in Asymptomatic Middle-Aged Individuals With Cardiometabolic Risk Factors
Structured PICO
P
Population
Asymptomatic middle-aged individuals free of known cardiovascular disease
O
Outcome
Coronary microvascular function and atherosclerosis progressionsurrogate
Impaired coronary microvascular function is linked to cardiometabolic risk factors and predicts faster atherosclerosis progression in asymptomatic middle-aged individuals.
Abstract
In asymptomatic middle-aged individuals free of known cardiovascular disease, the presence of cardiometabolic risk factors and systemic (poly-vascular) subclinical atherosclerosis are associated with impaired coronary microvascular function. Better coronary microvascular function reduces atherosclerosis progression at follow-up. (Progression of Early Subclinical Atherosclerosis PESA; NCT01410318).