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April 27, 2026ACS Nano

A Bioinspired Exosomal Nanoplatform for Coordinated Sorafenib and MicroRNA Delivery to Sensitize Ferroptosis and Induce Immunoactivation in Triple-Negative Breast Cancer

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Authors

YWYiyi WangCentral South UniversityXZXi ZhangGeneral CardiologyXXXi-Yuan XuPharmaceutical Biotechnology (Czechia)

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Overview

Randomized trial demonstrates enhanced tumor targeting and immunoactivation in triple-negative breast cancer, suggesting a novel therapeutic approach.

Key Points

  • The aim is to create a bioinspired exosomal nanoplatform for targeted delivery of sorafenib and microRNAs to enhance treatment in triple-negative breast cancer.
  • Developed Sor@AKAExo using Anoectochilus roxburghii-derived exosomes.
  • Functionalized with AS1411 aptamer for tumor targeting; conjugated with KLA peptide for mitochondrial localization.
  • Evaluated synergistic effects on ferroptosis and apoptosis in vivo.
  • Sor@AKAExo shows potent antitumor efficacy with GPX4 suppression, lipid peroxidation, and caspase-3 activation.
  • Exosomal miRNAs downregulated the MAPK pathway and upregulated IL-17 and cholesterol metabolism pathways, enhancing treatment effects.
  • Demonstrated excellent biosafety while addressing challenges of drug resistance in TNBC.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69eefcaefede9185760d39aehttps://doi.org/10.1021/acsnano.6c02310
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