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May 24, 2026Journal of NanobiotechnologyOpen Access

NK cell vesicles-based nanoplatform loaded with sorafenib synergizing ferroptosis and antitumor immunity against hepatocellular carcinoma

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Authors

CGChulan GongSZShenjie ZhangYFYuting Fan

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Overview

Randomized trial demonstrates synergistic effects on tumor growth in hepatocellular carcinoma, suggesting a new treatment avenue.

Key Points

  • This research aims to develop a nanotherapeutic strategy that enhances ferroptosis and antitumor immunity for treating hepatocellular carcinoma.
  • Fabricated natural killer cell derived nanovesicles (NK-NVs) using an extrusion method.
  • Loaded sorafenib onto NK-NVs via electroporation to form the NK-NVs-SRB complex.
  • Conducted in vivo experiments to evaluate tumor growth inhibition and immune activation.
  • NK-NVs-SRB intervention achieved a tumor growth inhibition rate of 44.54%.
  • The therapy effectively triggered ferroptosis in cancer cells and induced release of damage associated molecular patterns (DAMPs).
  • Activated anti-tumor immunity through recruitment of CD8 + T cell infiltration.

Cite This Study

Gong et al. (2026) studied this question.

synapsesocial.com/papers/6a12955d48a0ea166567182chttps://doi.org/10.1186/s12951-026-04550-8
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Also Consider

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  1. 1Targeted Ferroptosis-Immunotherapy Synergy: Enhanced Antiglioma Efficacy with Hybrid Nanovesicles Comprising NK Cell-Derived Exosomes and RSL3-Loaded Liposomes2024 · 23 citations
  2. 2A Bioinspired Exosomal Nanoplatform for Coordinated Sorafenib and MicroRNA Delivery to Sensitize Ferroptosis and Induce Immunoactivation in Triple-Negative Breast Cancer2026 · 2 citations
  3. 3Nanovaccines with ferroptosis, necroptosis and STING-activation for synergistic immunotherapy2026 · 2 citations
  4. 4Interplay between natural killer cells and ferroptosis: novel insights in tumor immunity and therapeutic potential2026 · 2 citations
  5. 5Nutrient Restriction Improves the Therapeutic Efficacy of Sorafenib by Inducing Ferroptosis via the NRF2/HO-1/GPX4 Pathway in Hepatocellular Carcinoma2026 · 2 citations