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September 5, 2026Drug DeliveryOpen Access

Synergistic epigenetic modulation and ferroptosis induction via codelivery of Decitabine and Sorafenib for potent anti-tumor therapy

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Authors

YXYujie XingXZXuan ZhangRWRui Wang

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Overview

Preclinical study demonstrates synergistic antitumor activity via exosome-micelle codelivery of decitabine and sorafenib in neuroblastoma models, highlighting a dual epigenetic-ferroptotic strategy.

Key Points

  • To determine whether an exosome-coated micellar platform codelivering decitabine and sorafenib synergistically enhances antitumor efficacy through simultaneous epigenetic remodeling and ferroptosis induction.
  • Engineered a biomimetic nanoplatform (Exo&PM/D + S) comprising sorafenib-loaded polymer micelles coated with decitabine-encapsulated exosomes.
  • Evaluated in vitro impacts on DNA demethylation, reactive oxygen species (ROS) accumulation, and cancer cell death.
  • Assessed tumor growth inhibition, antitumor immune activation, and survival outcomes in mouse neuroblastoma models.
  • Exo&PM/D + S demonstrated robust in vitro antitumor activity by concurrently amplifying DNA demethylation and intracellular ROS generation.
  • In mouse neuroblastoma models, the codelivery platform significantly suppressed tumor proliferation, elicited antitumor immune responses, and prolonged overall survival relative to control treatments.

Cite This Study

Xing et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd4046b95aff0620eb582https://doi.org/10.1080/10717544.2026.2726824
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Also Consider

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  1. 1A Bioinspired Exosomal Nanoplatform for Coordinated Sorafenib and MicroRNA Delivery to Sensitize Ferroptosis and Induce Immunoactivation in Triple-Negative Breast Cancer2026 · 2 citations
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  3. 3Dual-Regulated Nanodrug Potentiates Immunotherapy by Synergizing Ferroptosis with Radiotherapy to Reverse the Immunosuppressive Tumor Microenvironment2025
  4. 4Lipid Nanoparticular Codelivery System for Enhanced Antitumor Effects by Ferroptosis–Apoptosis Synergistic with Programmed Cell Death-Ligand 1 Downregulation2024 · 18 citations
  5. 5A Mutually Reinforcing Nanoplatform Orchestrates Immunogenic Ferroptosis and Reprogramming of Tumor-Associated Macrophages for Potent Immunotherapy2026