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This study investigates how serotoninergic control affects plasma beta-endorphin and beta-lipotropin levels in humans.

April 27, 2026Open Access

Serotoninergic agonists increase plasma levels of beta-endorphin and beta-lipotropin in humans.

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Randomized trial shows serotoninergic agonists elevate beta-endorphin and beta-lipotropin in humans, indicating a pathway for hormonal regulation.

This study investigates how serotoninergic control affects plasma beta-endorphin and beta-lipotropin levels in humans.
Administered L5-OH-triptophan intravenously and orally to investigate dose-response effects.
Measured hormone levels in men after acute administration of serotoninergic agents.
Evaluated the effects of fluoxetine and methysergide on hormone levels.
Intravenous L5-OH-triptophan resulted in a significant increase in beta-EP and beta-LPH (P < 0.01).
Oral administration produced variable increases in beta-EP and beta-LPH but was not dose-dependent.
Fluoxetine induced a significant dose-related rise in the hormones (P < 0.01), while methysergide blocked increases from L5-OH-triptophan.

Petraglia et al. (1984) studied this question.

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Randomized trial shows serotoninergic agonists elevate beta-endorphin and beta-lipotropin in humans, indicating a pathway for hormonal regulation.