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This research aims to explore how dopamine affects circulating beta-endorphin and related hormones in normal subjects.

April 27, 2026Open Access

Evidences for a Dopamine-Regulated Peripheral Source of Circulating B-Endorphin.

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Randomized trial examines dopamine's role in beta-endorphin regulation, indicating a new source in humans.

This research aims to explore how dopamine affects circulating beta-endorphin and related hormones in normal subjects.
Administered dopamine receptor agonists and antagonists to normal subjects.
Measured plasma levels of beta-endorphin, beta-lipotropin, cortisol, and prolactin before and after treatments.
Administered metoclopramide, domperidone, and optionally, dexamethasone to evaluate hormone responses.
Metoclopramide significantly increased plasma beta-endorphin, beta-lipotropin, prolactin, and cortisol levels (exact values not provided).
Domperidone selectively increased beta-endorphin levels without affecting other hormones after dexamethasone.
Dopamine appears to inhibit the secretion of proopiomelanocortin-related peptides from a peripheral source.

Genazzani et al. (1988) studied this question.

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