October 1, 1980The Journal of Clinical Endocrinology & Metabolism
Dopaminergic Control of Plasma Catecholamine and Aldosterone Responses to Acute Stimuli in Normal Man
Why the study?
Does bromergocriptine alter plasma catecholamine and aldosterone responses to acute stimuli in normal men?
Population
5 normal males on a constant 50-meq Na intake
Comparison
Bromergocriptine 2.5 mg three times a day for 4… vs Baseline (before BEC administration)
Design
Other
Follow-up
4 days
Authors
Discussion
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Member takes
Implication
Findings in healthy volunteers do not support practice changes; leaves open dopaminergic modulation of catecholamine and aldosterone secretion for further research.
Structured PICO
Does bromergocriptine alter plasma catecholamine and aldosterone responses to acute stimuli in normal men?
P
Population
5 normal males on a constant 50-meq Na intake
I
Intervention
Bromergocriptine (BEC) 2.5 mg three times a day for 4 days
C
Comparator
Baseline (before BEC administration)
O
Outcome
Plasma aldosterone (PA), norepinephrine (NE), and PRA responses to upright posture and isometric handgripsurrogate
Dopaminergic pathways exert a pronounced inhibitory effect on catecholamine secretion and selectively suppress adrenal angiotensin II-mediated aldosterone secretion in normal men.
Cite This Study
WHITFIELD et al. (1980) studied this question.