November 1, 1985Journal of Cardiovascular Pharmacology
Catecholamine, Renin, Aldosterone, and Arginine Vasopressin Responses to Lower Body Negative Pressure and Tilt in Normal Humans: Effects of Bromocriptine
Key result
Bromocriptine blunted plasma norepinephrine, renin activity, and aldosterone responses to lower body negative pressure and tilting, and induced hypotension with increased potassium and AVP.
Why the study?
Does bromocriptine alter the hormonal and hemodynamic responses to lower body negative pressure and tilting in normal humans?
Population
n=5 normal volunteers
Comparison
Bromocriptine prior to graded lower body… vs Absence of BEC treatment
Design
Other
Authors
Discussion
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Implication
Bromocriptine effects warrant caution during orthostasis; leaves open clinical relevance in patients with autonomic or volume disorders.
Structured PICO
Does bromocriptine alter the hormonal and hemodynamic responses to lower body negative pressure and tilting in normal humans?
P
Population
5 normal volunteers undergoing graded lower body negative pressure and tilting.
I
Intervention
Bromocriptine (BEC) prior to graded lower body negative pressure (LBNP) and tilting
C
Comparator
Absence of BEC treatment (graded LBNP and tilting without bromocriptine)
O
Outcome
Hormonal and hemodynamic response (plasma norepinephrine, plasma renin activity, aldosterone, potassium, arginine vasopressin, and blood pressure)surrogate
Bromocriptine blunts sympathetic and renin-angiotensin-aldosterone responses to orthostatic stress, leading to hypotension and compensatory increases in vasopressin and potassium.
Cite This Study
Mohanty et al. (1985) studied Normal volunteers (n=5). Bromocriptine vs. Absence of bromocriptine treatment was evaluated on Hormonal and hemodynamic response to graded lower body negative pressure and tilting. Bromocriptine blunted plasma norepinephrine, renin activity, and aldosterone responses to lower body negative pressure and tilting, and induced hypotension with increased potassium and AVP.