Why the study?
Does domperidone alter the norepinephrine response to exercise and sympathovagal balance in humans?
Population
15 subjects total: 6 Addison patients and 9 normal volunteers
Comparison
Domperidone vs Placebo
Design
Other
Authors
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Alerts clinicians to potential sympathoexcitation with domperidone; extends evidence for dopaminergic modulation of sympathetic nerves to humans in vivo.
Does domperidone alter the norepinephrine response to exercise and sympathovagal balance in humans?
Endogenous dopamine modulates norepinephrine release by human sympathetic nerves in vivo, as evidenced by the effects of the D2-like antagonist domperidone.
Mannelli et al. (1999) studied this question.
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