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April 27, 2026Journal of NanobiotechnologyOpen Access

Glycosylated nanoparticles for oral insulin delivery via glucose transporter to improve intestinal absorption

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Authors

YZYipiao ZhangSNShulan NiXZXingjie Zan

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Overview

Randomized trial demonstrates improved intestinal absorption of insulin in diabetes models, suggesting a new delivery method.

Key Points

  • The research aims to enhance oral insulin delivery by developing glycosylated nanoparticles that improve intestinal absorption.
  • Developed glucose-modified PLGA-lipid hybrid nanoparticles through W1/O/W2 double emulsion and surface functionalization.
  • Evaluated the nanoparticles in a type 1 diabetes mouse model to assess therapeutic outcomes.
  • Assessed insulin stability under gastric conditions and pH-responsive intestinal release.
  • The nanoparticles maintained insulin stability in gastric conditions, enabling effective release in the intestines.
  • Significantly improved insulin absorption through glucose transporter-mediated pathways in diabetic mice, leading to superior therapeutic outcomes.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69eefde9fede9185760d4b25https://doi.org/10.1186/s12951-026-04428-9
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